Abstract: Due to the special structure of the nasal cavity, the addition of functional excipients in nasal drugs can improve the transmembrane absorption of the active pharmaceutical ingredient or reduce the clearance of nasal mucocilia, which plays an important role in maintaining the effective concentration of active pharmaceutical ingredient in the target area and promoting the absorption of nasal mucosa. In this paper, the excipients used in drug new approved by the United States Food and Drug Administration(FDA) in the past decade were summarized, and the current research advances and safety evaluation of excipients for nasal drug were reviewed, providing ideas and references for the selection of excipients for nasal drug development.