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    伊伐布雷定的药物利用评价与临床合理性分析

    Drug Use Evaluation and Clinical Rationality Analysis of Ivabradine

      摘要
    • 摘要:
      目的 基于熵权-优劣解距离法(technique for order preference by similarity to ideal solution，TOPSIS)对伊伐布雷定进行药物利用评价(drug use evaluation，DUE)，并对其临床应用的合理性进行分析。
      方法 以伊伐布雷定说明书、临床指南、专家共识以及相关文献作为参考依据，对伊伐布雷定进行药物利用评价，基于熵权-TOPSIS法评价天津市胸科医院2022年1月—2022年12月使用伊伐布雷定的住院病例。
      结果 共评价226份病例，伊伐布雷定的应用合理性评价结果为合理35例(15.49%)，基本合理173例(76.55%)，不合理18例(7.96%)。用药不合理的问题存在于以下几个方面：给药方式(23.89%)、给药剂量(23.45%)、特殊人群(23.01%)、药物相互作用(22.12%)、注意事项(2.21%)、适应证(2.21%)和禁忌证(0.88%)。
      结论 基于熵权-TOPSIS法进行了伊伐布雷定的药物利用评价与临床合理性分析，该方法操作简单，数据可靠，结果直观，对临床合理用药具有参考意义和指导作用。

       

      Abstract:
      OBJECTIVE Based on entropy weight technique for order preference by similarity to ideal solution(TOPSIS), the drug use evaluation(DUE) of ivabradine was conducted and the rationality of clinical application was analyzed.
      METHODS Inpatient medical records using ivabradine from January 2022 to December 2022 in Tianjin Chest Hospital were evaluated by entropy weight-TOPSIS method.
      RESULTS Two hundred and twenty-six cases of medical records was evaluated, there were 35 cases(15.49%) of reasonable medical records, 173 cases(76.55%) of basically reasonable medical records, and 18 cases(7.96%) of unreasonable medical records. The problems of unreasonable drug use were as follows: administration method (23.89%), administration dosage(23.45%), special groups(23.01%), drug interactions(22.12%), precautions(2.21%), indications (2.21%) and contraindications(0.88%).
      CONCLUSION The drug use evaluation of ivabradine is conducted and the rationality of clinical application is analyzed based on entropy weight-TOPSIS method. The method is simple in operation, reliable in data and intuitive in results. The study has reference significance and guiding function in clinical rational application of drugs.

       

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