OBJECTIVE To analyze the monitoring results of the blood concentration of mycophenolic acid in renal transplant recipients, and to investigate the effect of physiological factors on mycophenolic acid exposure in renal transplant recipients.

METHODS A retrospective research method was used to summarize the information of inpatients treated with mycophenolate mofetil and their concentrations were measured in the kidney transplantation department of Zhengzhou No.7 People’s Hospital. The effects of physiological factors such as concentration distribution, gender, body weight, gene polymorphism, albumin and hemoglobin levels and renal function on mycophenolic acid exposure were analyzed and discussed.

RESULTS The area under drug-time curve(AUC_{0-12 h}) of mycophenolic acid in female recipients was significantly higher than that in male recipients. The AUC_{0-12 h} of mycophenolic acid in recipients with large body weight was lower than that in recipients with small body weight. There was no significant difference in AUC_{0-12 h} of mycophenolic acid in recipients with different genotypes. The AUC_{0-12 h} of mycophenolic acid in the normal albumin level group was higher than that in the low albumin group. The AUC_{0-12 h} of mycophenolic acid in the mild anemia group and the moderate to severe anemia group was higher than the normal group, the moderate to severe anemia group and the normal group had significant differences. The AUC_{0-12 h} of mycophenolic acid increased significantly in recipients with creatinine clearance less than 60 mL·min⁻¹. The difference between group 3(30 mL·min⁻¹≤creatinine clearance<60 mL·min⁻¹) and the normal group was statistically significant.

CONCLUSION The blood concentration of mycophenolic acid is affected by various physiological factors such as gender, body weight, serum protein level, and renal function. Blood concentration monitoring is required during individualized treatment.