Abstract: OBJECTIVE To explore the research status of drug control institutions and to analyze the research hotspots and frontier trends, so as to provide references for further research.METHODS Taking CNKI as the data source of Chinese literature, Web of Science Core Collection as the data source of English literature. Using CiteSpace 6.1.R6 visualization tool software, visualization analysis was conducted to the research status of drug control institutions in China from the aspects of author-institution cooperation, keyword co-occurrence, keyword cluster and burst analysis. Meanwhile, draw the relevant maps to do the compare.RESULTS A total of 3 711 Chinese literatures and 2 650 English literatures were included. The number of literatures issued by Chinese drug control institutions showed a rising trend. Ma Shuangcheng was the most prolific author, and National Institutes for Food and Drug Control was the most prolific research institution. Current research hotspots included content determination, fingerprinting, identification evaluation, dissolution mechanism and related substances combining specific drugs, as well as biotechnology, nanomaterials and toxicological substitution technologies. Frontier research trends mainly included drug quality research integrating advanced analytical technology and measurement methods, detection technology of frontier biological products, and continuous research on antibacterial active substances. CONCLUSION Researchers and institutions should grasp hotspots and trends, work at deepen cooperation and research, and provide intellectual support for improving ability of drug inspection and promoting the modernization of drug supervision.