Abstract: OBJECTIVE To study the application hotspot and development trend of medical digitalization based on the comparative analysis of domestic and foreign literatures and patents and to provide reference for its subsequent development. METHODS CiteSpace was used to search the CNKI Peking University core database and the Web of Science core database from 2000 to 2022, and statistical comparative analysis of the number of documents issued, the issuing organization, and the keywords of domestic and foreign documents were conducted, and the PatSnap platform was used to search the authorized invention patents of the China database(China Patent Database), the United States database(USPTO), and the global database (PatSnap). The statistics and comparative analysis were carried out on the number and patent application segmentation. RESULTS A total of 1 283 Chinese literatures and 1 545 foreign English literatures had been included in the study. The number of papers published in this field at home and abroad had continued to increase. The research focus was mainly on the Internet, information technology and medical applications. The domestic market was more inclined to build blockchain, big data and other platforms, while the foreign market was more inclined to the Internet of Things, cloud computing and other technology applications. In addition, a total of 52 208 authorized invention patents from the three major patent databases of the United States, China and the world were included in the study. China's authorized invention patents grew strongly, with an average growth rate of 24.14%, which was 8.68 percentage points higher than that of the United States. The average growth rate in the past three years was 24.50%. The global share continued to increase, from 10.35% in 2020 to 16.48% in 2022. China's image analysis, image enhancement, computer tomography scanner and other aspects had a large proportion of invention patents, and the United States had obvious innovation advantages in special data processing, drugs or prescriptions, and bioelectric signal measurement. CONCLUSION The hot spots of medical digital application present a diversified development trend, and the hot spots at home and abroad present differences. It is suggested that the development of domestic medical digital application emphasize practicality, and guide the research and development of digital technology with accurate demand; Pay attention to application, and let digital technology be applied to meet the medical and health needs of the people, and strengthen international cooperation and jointly develop international markets.