Abstract: OBJECTIVE To construct pre-review rules and a knowledge base of rational drug use in tube feeding, and evaluate its intervention effect on irrational medical orders. METHODS The data of irrational medical orders in tube feeding from January to August 2021 in Zhongda Hospital Southeast University for inpatients were retrospectively collected and analyzed in terms of drug types and dosage forms which wasn’t suitable for tube feeding, and the review rule for rational drug use of tube feeding was set. The irrational medical orders were intervened by pre-review system cooperated with pharmacists, and the results were compared before and after the intervention. RESULTS The drug dosage forms of irrational medical orders involved enteric-coated preparations, controlled and sustained-release preparations, soft capsules or drop pills, injection. After the intervention by pre-review system and pharmacists, the irrational medical order base for rational drug use of tube feeding were significantly decreased from 5.59% to 3.31%(P<0.001). CONCLUSION The establishment of pre-review rule base for rational drug use of tube feeding and the intervention of the irrational medical orders contribute to make better medication decisions by physicians and reduce the occurrence of medication errors.