Abstract: OBJECTIVE To systematically evaluate the transformation effect of pharmaceutical care of pharmacists in China, and to provide reference for pharmacists to carry out pharmaceutical care in the future. METHODS Retrieved from PubMed, Embase, Cochrane Library, Web of Science, CBM, CNKI, Wanfang and VIP database, randomized controlled trials(RCTs) and non-randomized studies of interventions(NRSIs) about pharmaceutical care carried out by pharmacists with clear outcome evaluation indicators were collected. Related scales used to evaluate the quality of the included literatures after literature screening and data extraction, and meta-analysis was conducted by using RevMan 5.4 software. RESULTS A total of 51 studies were included, including 8 RCTs and 43 NRSIs. Meta-analysis showed that the prescription rationality of antibioticsOR=5.17, 95%CI(4.10, 6.52), P<0.000 01, single use rate of antibioticsOR=2.87, 95%CI(2.16, 3.81), P<0.000 01, patient complianceOR=3.40, 95%CI(1.73, 6.66), P=0.000 4 and patient satisfactionOR=2.54, 95%CI(1.58, 4.10), P=0.000 1 in the trial group were significantly better than those in control group. The proportion of unreasonable prescriptionsOR=0.29, 95%CI(0.22, 0.37), P<0.000 01, incidence of adverse drug reactionsOR=0.17, 95%CI(0.12, 0.24), P<0.000 01, cost and duration of treatment(P<0.05) in the trial group were significantly lower than those in control group. CONCLUSION Prescription audit, medication consultation, medication education, prescription review, adverse drug reaction reporting and other pharmaceutical services carried out by pharmacists have achieved remarkable results. This transformation meets the requirements of the state for pharmacists, and can also provide guarantee for clinical rational drug use.