Abstract: OBJECTIVE To study the effects of 6 kinds of endophytes on the degradation of 5 pesticide residues and the conversion of 20 saponin monomers in the stem and leaves of ginseng. METHODS Under the same culture conditions, the contents of pesticide residues and ginsenosides in the stems and leaves of ginseng before and after treatment with 6 kinds of endophytes were determined by GC and HPLC, respectively. The pesticide residue rate and ginsenoside conversion rate of 6 kinds of endophytie in stems and leaves of ginseng were calculated. The effects of endophytes on the quality of transformation products of stems and leaves of ginseng were evaluated, and the strains with good effect of reducing agricultural residues and transforming ginsenosides were selected. RESULTS Six kinds of ginseng endophytes could degrade five kinds of pesticide residues in ginseng stems and leaves, among which Bacillus polymyxa had the strongest degradation effect on pesticide residues. The degradation rates of fluazinam, benzene hexachloride, pentachloronitrobenzene, chlorpyrifos and dichlorodiphenyltrichoroethane were 86.90%, 88.89%, 79.88%, 86.12% and 86.67%, respectively(P<0.05). It could transform 20 kinds of monomer saponins, among which Bacillus lysine and Bacillus cereus had the strongest effect on transforming ginseng stem and leaf saponins, and the sum values of 20 monomer saponins were 5.84% and 5.85% respectively(P<0.05). CONCLUSION The 6 kinds of endophytes have different effects on pesticide residue degradation and conversion of saponins in ginseng stems and leaves, the Paenibacillus polymyra have the best degradation effect on pesticide residues, Bacillus bsine and Bacillus cereus have the best effect on transforming ginsenosides, which provide theoretical basis for improving the total ginsenosides of ginseng stems and leaves.