Abstract: OBJECTIVE To study on medication rules and mechanism of traditional Chinese medicine in treating functional dyspepsia(FD) based on data mining and network pharmacology.METHODS The relevant literature on clinical treatment of FD from database establishment to November 2021 was searched in CNKI, Wanfang Data and VIP databases to establish prescription database. After standardizing the information of traditional Chinese medicine, WPS Office was used to analyze the prescription medication rules, including medication frequency, four-qi, five-flavor, meridian-tropism and efficacy; cluster analysis with ancient and modern medical records cloud platform; using SPSS Modeler software for association rules analysis and complex network analysis, the core drugs were obtained; search the active ingredients and targets of core drugs in TCMSP database; retrieve FD targets in OMIM and GeneCards databases; venny was used to target the intersection of core drugs and FD; using Cytoscape software to make “disease-drug-component-target” network; PPI analysis of intersection targets using String database; GO and KEGG enrichment analysis of intersection targets were performed by Metascape database.RESULTS A total of 274 prescriptions were screened, including 179 herbs. There were 24 Chinese herbs with the frequency of use≥34, and Glycyrrhizae Radix et Rhizoma ranked first in 196 times; in the four nature of drugs, the moderate-temperature drugs, mild drugs and cold drugs were most frequently used; the top three of the five flavors were pungent, bitter and sweet herbs; the main meridians were spleen meridian, stomach meridian and lung meridian; the highest frequency of efficacy followed by eliminating dampness and phlegm, clearing heat and removing toxicity, dispersing stagnated liver qi for relieving qi stagnation; two association rules showed that Atractylodis Macrocephalae Rhizoma-Poria support the highest, three association rules Poria-(Atractylodis Macrocephalae Rhizoma, Glycyrrhizae Radix et Rhizoma) support the highest; three clusters were obtained by cluster analysis; complex network analysis showed that Glycyrrhizae Radix et Rhizoma, Atractylodis Macrocephalae Rhizoma, Poria, Codonopsis Radix and Bupleuri Radix were essential in the prescription; based on the pathogenesis, drug efficacy and data mining results of FD, Glycyrrhizae Radix et Rhizoma, Atractylodis Macrocephalae Rhizoma and Codonopsis Radix were selected as the core drugs. The main active components were luteolin, formononetin, glycitein and so on. The core targets were AR, ESR1, MAPK1, F2, SLC6A4, IL-2, IL-4, IL-6 and IL-10. The main signaling pathways were PI3K-AKT, AGE-RAGE and HIF-1, et al.CONCLUSION Core drugs can be aimed at the pathogenesis of FD spleen deficiency and qi stagnation, invigorating spleen and benefiting stomach, regulating qi and guiding stagnation, and its high frequency drugs play a role in eliminating dampness and phlegm, clearing heat and relieving depression. At the same time, the treatment of FD is through multi-target, multi-pathway synergistic interaction.