Abstract: OBJECTIVE To establish the stir-frying with wine process of Achyranthis Bidentatae Radix in the classical famous prescription of Wenjing decoction, and to compare the pharmacological effect before and after processing.METHODS Combined with the ancient and modern methods, the cleansing, moistening, cutting and drying process were preferred, and the one-factor investigation combined with the multi-index comprehensive scoring method was used to study the Achyranthis Bidentatae Radix processing method. The effect of the Achyranthis Bidentatae Radix before and after processing was compared by the rat torsion reaction and blood rheology.RESULTS The optimum stir-frying with wine process of Achyranthis Bidentatae Radix was as follows: clean Achyranthis Bidentatae Radix, wash with water quickly(water volumn was 3-4 times of the mass of herb), moisten, section, dry at low temperature or dry naturally, then take 100 g, mixed with rice wine 10 g and water 10 g,stuffy for 3 h; then stir-fry 25 min in frying pan(30 r·min^-1) which has preheated to 130 ℃. Compared with the model group, the whole blood viscosity was significantly decreased(P<0.05 or P<0.01) in Achyranthis Bidentatae Radix group and the wine-processed group, indicated that the effect of promoting blood circulation and removing blood stasis of wine stir-fried Achyranthis Bidentatae Radix was better than Achyranthis Bidentatae Radix.CONCLUSION The optimazed process is stable and feasible with good repeatability. It's reasonable to use wine stir-fried Achyranthis Bidentatae Radix in the Wenjing decoction.