Abstract: OBJECTIVE To establish a quality evaluation model of Anemarrhenae Rhizoma using the entropy weight method combined with the gray correlation method and the TOPSIS method for evaluating the quality of Anemarrhenae Rhizoma and its processed products from different origins. METHODS The contents of water, mangiferin, timosaponin B II, total polysaccharide, glycoprotein and uronic acid and polysaccharide yield were chosen as detection indexes for Anemarrhenae Rhizoma, the weight was calculated by entropy weight method, and the indexes were statistically analyzed by gray correlation method and TOPSIS method. Through statistical analysis, a quality evaluation model of Anemarrhenae Rhizoma was established to comprehensively inspect the quality of 15 batches of Anemarrhenae Rhizoma from 3 production areas, including Xinzhou, Anguo and Hanzhong, and its processed products. RESULTS The indexes of Anemarrhenae Rhizoma from different regions and batches were quite different. Comparing the changes before and after processing, it was found that the moisture content decreased, the saponin content decreased, and the polysaccharide content increased. Fifteen batches of Anemarrhenae Rhizoma and processed products quality ranking results TOPSIS were in good consistency with the gray relational analysis. CONCLUSION The quality evaluation model is established by the combined application of gray correlation method and TOPSIS method based on entropy weight method, it is simple and effective, and can be used for the quality evaluation of Anemarrhenae Rhizoma.