Abstract: In this paper, the general situation of Ganoderma and Ganoderma spore powder, the wall removal and wall breaking technology of Ganoderma spore powder, and the identification method of Ganoderma spore powder were reviewed. The toxicology of Ganoderma spore powder research(including acute toxicity test, genotoxicity test, repeated administration toxicity, juvenile animal toxicity studies, etc.) are sorted and summarized, existing literature shows that Ganoderma and Ganoderma spore powder are safe in the above toxicology tests without obvious toxicity.