Abstract: OBJECTIVE To explore the efficacy and safety of pantoprazole in the prevention of stress ulcer induced by acute cerebral infarction combined with the application of anti-platelet drugs. METHODS Retrospective analysis was performed on patients diagnosed with acute cerebral infarction who received antiplatelet drugs and pantoprazole for prevention of stress ulcer from January 1st, 2021 to July 30th, 2021 in Tongde Hospital of Zhejiang Province. According to inclusion and exclusion criteria, a total of 200 effective cases were included, including 96 patients collecting and injected with pantoprazole as experimental group and 104 patients non-collecting with pantoprazole as control group. Univariate analysis, binary logistic regression analysis and subgroup analysis were performed between the two groups using R3.6.1, to compare the efficacy and safety of them in preventing the risk of stress ulcer and to analyze the related factors affecting the effectiveness outcome. RESULTS In terms of effective outcome indicators of incidence of irritability ulcer, univariate and multivariate regression analysis showed that, comparing with the non-collecting with pantoprazole group, there was no statistical difference in the efficacy and safety of the treatment group in the prevention of stress ulcer induced by acute cerebral infarction combined with the application of anti-platelet drugs. The results of risk and subgroup analysis showed that there might be a certain population difference in the prevention of stress ulcer by using pantoprazole in different age groups. CONCLUSION Centrally collected and non-centrally collected pantoprazole have consistent efficacy in preventing the risk of stress ulcer in acute cerebral infarction patients combined with the use of antiplatelet drugs. Pantoprazole can be applied safely in clinical practice.