Abstract: Alopecia is probably one of the common adverse reactions for oncological patients. Antineoplastic drugs, including cytotoxic chemotherapy drugs, targeted agents, immune checkpoint inhibitors and endocrine drugs could induce alopecia to varying degrees. Although hair loss is not life-threatening, and it is often underestimated by physicians compared to other adverse drug reactions. But it negatively influences body image, sexuality and self-esteem. Even some patients experienced anxiety or depression, which further reduced their quality of life. Therefore, this article reviews the literature related to hair loss caused by anti-tumor drugs, in order to provide clinical reference value for cancer patients with hair loss.