Abstract: OBJECTIVE To explore the role of clinical pharmacists in anticoagulant treatment of venous thromboembolism after vascular shunt in pediatric patients with portal hypertension. METHODS Clinical pharmacists participated in the anticoagulant treatment of one case of a child with portal hypertension after vascular shunt combined with venous thromboembolism, analyzed the risk factors and therapy of pediatric venous thromboembolism, and assisted surgeons in drug selection, dosage adjustment and discharge medication through pharmaceutical consultation. RESULTS The pharmaceutical consultation advice was adopted. The pediatric patient's venous thromboembolism had been controlled in time and discharged from hospital. CONCLUSION Clinical pharmacists' participating in consultations can improve the rational use of anticoagulant drugs and minimize the bleeding risk of anticoagulants, providing references for the prevention and treatment of postoperative venous thromboembolism in pediatric patients.