Abstract: At present, China vigorously develops the alternative use of generic drugs to save medical costs and improve the accessibility of drugs, but there are still some deficiencies. By analyzing and summarizing the factors influencing generic drugs substitution, combining with the current development situation of generic drugs substitution in China, some substantive measures and suggestions are put forward from the perspective of pharmacists, in order to better play the professional value of pharmacists and provide some reference for promoting generic drugs substitution.