Abstract: OBJECTIVE To explore the preparation of new crystal forms of ticagrelor, optimize the preparation process, meanwhile, conduct characterization and dissolution studies. METHODS Using solvent mediation of ticagrelor crystal form Ⅱ into a new crystal form. The new crystal form of ticagrelor was characterized by powder X-ray diffraction, infrared spectroscopy, and differential scanning calorimetry. The equilibrium solubility of ticagrelor crystal form Ⅱ and new crystal form in simulated gastric fluid(pH 1.2 hydrochloric acid solution), simulated intestinal fluid(pH 6.8 phosphate buffer solution) and 30% ethanol/water solution were determined. RESULTS The 2θ values of the new crystal form ticagrelor had characteristic absorption peaks at 5.49°, 11.01°, 12.48°, 13.88°, 16.86°, 17.34°, 18.21°, 18.87°, 19.34°, 20.12°, 21.29°, 22.02°, 22.68°, 24.03°, 25.44°, 28.24°, 31.03°, which were obviously different from other crystal forms. CONCLUSION In simulated gastric fluid (pH 1.2 hydrochloric acid solution) and simulated intestinal fluid(pH 6.8 phosphate buffer solution), the equilibrium solubility of ticagrelor new crystal form is about 0.89 times that of ticagrelor crystal form II; In 30 % ethanolwater solution, the equilibrium solubility of ticagrelor new crystal form is about 1.75 times that of ticagrelor crystal form II.