Abstract: OBJECTIVE To form a precise dosing mode of voriconazole by constructing a decision tree, to provide accurate suggestions for clinical decision-making of voriconazole medication. METHODS Clinical pharmacists obtained patient-related data and integrated information by synthesizing liver function, concomitant medication, gene polymorphism and other relevant factors to construct a decision tree model for precise dosing of voriconazole, and based on the decision tree to provide the corresponding initial treatment plan. Later adjustments were made according to the monitoring of blood drug concentration. RESULTS According to the decision tree model, a comprehensive analysis of the related influencing factors before and after the administration of voriconazole was conducted to provide safe and effective medication recommendations for clinical practice, and to optimize and adjust. CONCLUSION The decision tree model of voriconazole precision dosing is applied to provide individualized drug regimen for clinical practice, guarantee the efficacy and safety of voriconazole, and reflect the work value of clinical pharmacists.