Abstract: Gut microflora plays an important role in material information transmission and metabolism. With the progress of biotechnology, researchers have a further understanding of the relationship between gut microflora and host health. Recent studies have found that there is a correlation between gut microflora and the toxicity of some drug. This paper reviews the research on gut microflora related to drug hepatotoxicity, nephrotoxicity, neurotoxicity, reproductive and juvenile toxicity, in order to provide reference for drug toxicology research.