Abstract: OBJECTIVE To summarize the research hotspots and evolution trends in the field of pharmacovigilance digitization and put forward the enlightenment by analyzing the literature in the field of pharmacovigilance digitization research. METHODS The core literatures in the field of global pharmacovigilance digital research from 2002 to 2022 were retrieved from Web of Science database. Knowledge Graph analysis of the temporal distribution, spatial distribution, keyword co-occurrence, keyword clustering and keyword emergence of the study was performed using CiteSpace V Software. RESULTS A total of 1 103 articles were included in the study, and the number of publications increased rapidly in the past five years. The countries with the highest number of publications were the United States, China, Britain, France and Italy, and the institutions with the highest number of publications were the Uppsala Monitoring Center, the French National Institute of Health and Medical Research and the U.S. Food and Drug Administration. Research hotspots focused on adverse drug reaction signal detection, drug safety and risk assessment, reporting system and database information mining, etc. Future research trends were to explore the application of social media, deep learning, artificial intelligence, internet of things in pharmacovigilance. CONCLUSION The research of pharmacovigilance digitization is in the developing stage and it’s helpful to improve the efficiency and level of pharmacovigilance by constructing a digital ecosystem for pharmacovigilance, strengthening the cultivation of diversified and complex talents and optimizing pharmacovigilance digital technology.