Abstract: OBJECTIVE To sort out the nature and flavor, efficacy, classification, original plant and main application medicinal materials of Tibetan medicine Rubi Subornati Caulis. METHODS By systematically consulting traditional and modern Tibetan medicine books and Tibetan medicine standards in various regions, conducting literature textual research, sorting out the nature and flavor, effect, classification, original plant and analyzing the main application medicinal materials of Tibetan medicine Rubi Subornati Caulis in Tibetan areas based on literature and field investigation. RESULTS Rubi Subornati Caulis was sweet, bitter, acerbity and slightly acrid, the nature of Rubi Subornati Caulis was cool. It could treat wind-heat, peigen disease, edema, and also could treat influenza. It was very effective for cold, aversion to cold and fever, head and body pain, upper respiratory tract infection and pulmonary disease. Rubi Subornati Caulis(ཀཎྜ་ཀ་རི།) was divided into white Rubi Subornati Caulis(ཀཎྜ་ཀ་རི།) and purple Rubi Subornati Caulis(ག་བྲ།), the color of the flowers and branch was the basis for the classification of Rubi Subornati Caulis. It was considered that Rubus biflorus Buch.-Ham. ex Smith. and Rubus subornatus Focke. were in conformity with the description of original plant of ancient herbal Rubi Subornati Caulis. R. biflorus Buch.-Ham. ex Smith., R.subornatus Focke. and Rubus subornatus Fooke var. melanadenus, Rubus sachalinensis Lévl. and Rubus niveus Thunb. were the commonly used species recorded in the literature. CONCLUSION The results of this study can guide the improvement of the quality standard of Tibeta medicine Rubi Subornati Caulis, and guarantee the safe, reasonable and effective drug use in clinical practice.