Abstract: Neoantigen is tumor specific antigen and a promising target for tumor immunotherapy. However, due to the complex physiological process of neoantigen generating and stimulating T cell response, it’s still a huge challenge to discover and identify neoantigen efficiently. With the accumulation of tumor immunogenomics data and the in-depth study of artificial intelligence prediction methods, researchers could take advantage of artificial intelligence algorithms for neoantigen prediction methods, laying a solid foundation for tumor immunotherapy based on neoantigens. The research reviewed the advances in tumor neoantigen prediction methods for antigen processing and presenting, as well as antigen recognition by T cells.