Abstract: OBJECTIVE To explore the application effect of quality control circle(QCC) method in improving the management of narcotic drugs in intelligent surgical pharmacy. METHODS The QCC was established and the PDCA method was applied to promote the improvement project. The key points of improving the management of narcotic drugs in surgical pharmacy were determined by Plato and 80/20 rule, the key causes were derived by fish-bone diagram, and the measures were determined. Compared the unqualified rate before and after the improvement to explore the effectiveness of the QCC method. RESULTS The unqualified rate of narcotic drug management in surgical pharmacies decreased significantly from 24.44% to 8%, yield rate was 117.77%, and the progress rate was 67.27%. The improvement focus that the missing/wrong registration of residual liquid and the error patient information on formula decreased by 57.5% and 90.6% respectively. CONCLUTION The management of the disposal of residual liquid and the standardization of narcotic prescription has been significantly strengthened. The QCC method can effectively improve the management level and efficiency of narcotic drugs in surgical pharmacy, which not only promotes the drug safety of patients, but also promotes the construction of intelligent surgical pharmacy.