Abstract: OBJECTIVE To construct the digital-intelligent pharmaceutical brain system, and explore the new model of drug management in hospital, providing reference for the digital-intelligent management of pharmacy in medical institutions. METHODS The framework and management of the digital-intelligent pharmaceutical brain system were systematically introduced, and its application effect was evaluated. RESULTS After the implementation of the digital-intelligent pharmaceutical brain, the time of taking medicine was shortened, and the number of ineffective drugs was reduced, ensured the timeliness and safety of medication for patients; the work intensity was reduced, the work efficiency was improved, the dispensing errors were reduced, and the work flow was improved, improved the level of hospital pharmacy management. CONCLUSION The new model of drug management based on the digital pharmaceutical brain is helpful to promote digital-intelligent reform of hospitals, strengthens the level of pharmaceutical management, and improves the quality of medical services.