Abstract: Tablets have always been an important preparation in clinical application, but the development and design mode, quality evaluation technology and production quality control mode of tablets can hardly meet the current demand. This paper summarized the application of multivariable data analysis technology, artificial neural network technology and 3D printing technology in the design and development of tablets to meet the rapid preparation and personalized production of tablets. It also discussed the near infrared optical technology, terahertz pulse imaging technology, nuclear magnetic resonance imaging technology and other new detection technologies in the quality evaluation of tablets. Compared with the traditional detection technology, the new detection technology is efficient, sensitive and convenient. At the same time, it follows the concept that quality originates from design in establishing the quality control strategy for the development and production of tablets. It is of great significance to improve the safety and effectiveness of tablets as well as the development and production of tablets.