Abstract: As a drug carrier with low toxicity and immunogenicity,liposomes have been used in the delivery of insoluble,unstable and toxic drugs.However,traditional liposomes still have some defects,such as poor stability,insufficient circulation time in vivo,and unclear active targeting,therefore,it is necessary to select appropriate modified materials to prepare liposomes.The methods of modifying liposomes mainly include adding surfactants or modified substances to the membrane materials,inserting targeted ligands on the membrane surface,or coupling the ligand with the membrane materials to form the liposomes structure.This paper summarizes the commonly used modification materials of liposomes in recent years,explains the modification principle and analyzes its advantages and disadvantages,so as to provide reference for the research and development of liposomes.