Abstract: OBJECTIVE To determine the residue of 7 heavy metals(Pb, Cd, As, Hg, Cu, Cr, Ni) in Ganoderma spore powder and to evaluate the health risk of dietary exposure. METHODS A total of 40 batches of Ganoderma spore powder(including Chinese traditional medicine decoction pieces, health food, food and agricultural products) were collected for detection, and the dietary exposure of 7 heavy metal element in Ganoderma spore powder was evaluated by the method of point estimation. RESULTS Among the 40 batches of Ganoderma spore powder, the detection rate of 7 heavy metal elements was 100%, and the residue of heavy metals in 8 batches was exceeded the proposed limit, the result of dietary exposure assessment showed that there was a certain health risk of dietary exposure of Cr in the consumption of Ganoderma spore powder. CONCLUSION The dietary exposure of 6 heavy metals(Pb, Cd, As, Hg, Cu, Ni) in Ganoderma spore powder is lower than the temporary tolerable intake, and the risk to human health is acceptable. The maximum dietary exposure and P₉₅ value of Cr is exceeded the temporary tolerable intake, and there is a certain health risk.