Abstract: OBJECTIVE To confirm the reasonableness and scientificity of Qu Aurantii Fructus medicinally used as Aurantii Fructus,so as to restore its legal status as Aurantii Fructus.METHODS A textual research on the history of Qu Aurantii Fructus as the medicinal use of Aurantii Fructus was carried out.Through experimental study and literature research for morphological characteristics,cold resistance gene and gene sequencing were carried out to confirm the plant origin.The traceability of its plant base was studied.The chemical constituents were studied in literature and experiment,and the pharmacodynamics was studied.The quality of Qu Fructus Aurantii and the Aurantii Fructus of Chinese Pharmacopoeia 2020 edition were compared.RESULTS Qu Aurantii Fructus had a medicinal history about 300 years.Its plant source was Citrus aurantium'Changshan-huyou',and its chemical composition was similar to that of Citrus aurantium Linn.The medicinal efficacy of Qu Aurantii Fructus was consistent with that of Aurantii Fructus in Chinese Pharmacopoeia 2020 Edition,and its quality indicators met the requirements of Chinese Pharmacopoeia 2020 Edition,the average qualified rate was higher than that of Aurantii Fructus in Chinese Pharmacopoeia 2020 Edition.CONCLUSION The legal status of Qu Aurantii Fructus medicinally used as aurantii Fructus should be restored,Citrus aurantium'Changshan-huyou'should be used as one of the original plans of aurantii Fructus in Chinese Pharmacopoeia.