Abstract: OBJECTIVE To study clinical pharmacists participate in the management of antibiotics in elderly patients with acute pancreatitis in Department of Gastroenterology, so as to provide reference for clinical rational use of antibiotics. METHODS Clinical pharmacists took measures to participate in the management of antibiotics in elderly patients with acute pancreatitis in the Department of Gastroenterology. The elderly patients with acute pancreatitis who used antibiotics in the Department of Gastroenterology from January to July in 2019 and January to July in 2020 were collected and compared before and after the management of clinical pharmacists. RESULTS There was no significant difference in age, gender, improvement rate of clinical symptoms and negative conversion rate of serum amylase between before and after the management of antibiotics. The length of stay after management was significantly reduced(P<0.05). The total amount of antibiotics used, the average amount of antibiotics used per person, the total days of using antibiotics, the amount of antibiotics used, the cumulative defined daily dose number of antibiotics, and the number of cases of combined use of antibiotics were reduced less. The dosage of latamoxef was higher in elderly patients with acute pancreatitis. CONCLUSION Clinical pharmacists participating in the clinical management of antibiotics improved the level of rational use of antibiotics in gastroenterology, reduced the use of antibiotics and the medical expenses of patients.