Abstract: Melasma is an acquired pigmentation disease, which plagues the work and life of patients. The main challenge of topical transdermal drug delivery is the barrier of drug penetration through the stratum corneum barrier. As a physical penetration enhancement method and a new drug delivery system, microneedles can penetrate the stratum corneum to form a specific drug delivery channel, which can promote drug penetration and improve drug bioavailability. This paper mainly summarizes the characteristics of microneedles and takes melasma as an entry point to analyze the application research of microneedles in the field of melasma in recent years, and provides certain insights for the subsequent development of microneedle products for melasma.