Abstract: The incidence of skin-related diseases is increasing year by year, most skin diseases are mainly treated with preparations, but there are some problems such as low transdermal rate and poor stability. D-α-tocopherol polyethylene glycol succinate(TPGS) has the dual functions of polyethylene glycol and vitamin E, and can be used as solubilizer, penetration enhancer, emulsifier and stabilizer in drug delivery system. TPGS has also been widely used to improve the solubility, stability, encapsulation rate, drug loading and transdermal absorption rate of drugs. In this paper, the physical and chemical properties of TPGS, the application of TPGS as pharmaceutical excipients, the application of TPGS in nanocarrier system and the application of TPGS nanocarrier in the treatment of skin diseases are reviewed, so as to provide reference for the development of new TPGS nanocarriers for the treatment of skin-related diseases.