Abstract: OBJECTIVE To discuss hot-melt pressure-sensitive adhesive plaster matrix and the preparation technology of hot-melt pressure-sensitive adhesive plaster. METHODS The reasonable hot-melt pressure-sensitive adhesive matrix components were analyzed by different formulation. Combined with the equipment, the production process and the key points of production operation of hot-melt pressure-sensitive adhesive plaster were discussed. The advantages, existing problems and solutions of hot-melt pressure-sensitive adhesive paste production were analyzed, and the development of hot-melt pressure-sensitive adhesive plaster was also prospected. RESULTS The hot-melt pressure-sensitive adhesive, which was composed of polymer matrix, plasticizer and tackifier according to the general provisions of the 2020 edition of the "Chinese Pharmacopoeia", was more suitable as a matrix for hot-melt pressure-sensitive adhesive plaster. Mixing and coating were the key positions in the production of hot-melt pressure-sensitive adhesive plaster. Low temperature operation and reasonable dosing sequence could reduce the loss of active ingredients of drugs. Good gas permeability framework materials and small molecular weight and highly compatible drugs were conducive to drug release. The hot-melt pressure-sensitive adhesive matrix made of hydrophilic material can improve its sweat resistance. CONCLUSIONS Compared with natural rubber plaster, the production of hot-melt pressure-sensitive adhesive plaster has beautiful appearance, comfortable application, non-biological irritant, less allergy, less equipment investment, simple process, high production efficiency, safety and environmental protection. In the future, natural rubber will be replaced by hot-melt pressure-sensitive adhesive as the matrix of plaster, and the hot-melt pressure-sensitive adhesive plaster has a better development prospect.