Abstract: OBJECTIVE To explore the role of clinical pharmacists in individualized and whole-process drug therapy of obstructive sleep apnea-hypopnea syndrome (OSAHS) related refractory hypertension. METHODS Clinical pharmacists participated in the drug treatment of a patient with OSAHS-related refractory hypertension, paying attention to the antihypertensive efficacy and adverse reactions, provided professional pharmaceutical advice on drug optimization and adjustment in the treatment process, and provided medication guidance.RESULTS The patient's blood pressure and heart rate were well controlled through the optimization of the treatment plan, which avoided the occurrence of serious adverse reactions and improved the trust of doctors and patients to clinical pharmacists.CONCLUSION Clinical pharmacists' in-depth clinical care of patients with refractory hypertension related to OSAHS can improve the compliance rate of patients' blood pressure, medication safety and compliance, improve the compliance rate of blood pressure, and promote rational clinical medication.