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    丹参川芎嗪注射液对心绞痛疗效及血脂影响的meta分析

    Meta-analysis of Blood Lipid Level in the Treatment of Angina Pectoris with Salvia Miltiorrhiza Ligustrazine Hydrochloride Injection

      摘要
    • 摘要: 目的 评价丹参川芎嗪注射液治疗心绞痛的疗效及其对血脂水平的影响。方法 计算机检索Cochrane Library、Pubmed、Embase、知网、万方、维普等数据库，检索时限均为建库至2021年2月19日。由2名研究者独立筛选文献、提取资料并评价偏倚风险，采用Review Manager 5.3软件进行meta分析。结果 共纳入16项研究，包括1 631例患者。Meta分析结果显示，与西药常规疗法相比，联合丹参川芎嗪注射液治疗心绞痛总疗效OR=3.88，95% CI(2.80，5.37)，P<0.000 01更好。血清总胆固醇水平MD=–1.08，95%CI(–1.36，–0.81)，P<0.000 01、甘油三酯水平MD=–0.52，95%CI (–0.66，–0.37)，P<0.000 01、低密度脂蛋白水平MD=–0.74，95%CI(–0.94，–0.55)，P<0.000 1低于对照组；高密度脂蛋白水平高于对照组MD=0.28，95%CI(0.20，0.36)，P<0.000 01。不良反应发生率亦低于对照组OR=0.57，95%CI(0.30，1.08)，P=0.008。结论 联合使用丹参川芎嗪注射液治疗心绞痛疗效明确，能有效改善血脂且不增加不良反应发生率。

       

      Abstract: OBJECTIVE To evaluate the efficacy and safety of Salvia Miltiorrhiza Ligustrazine Hydrochloride injection in the treatment of angina pectoris and its effect on hyperlipidaemia. METHODS Cochrane Library, Pubmed, Embase, CNKI, WanFang Data, VIP and other databases were searched by computer, and the searched time was from the database to February 19, 2021. Two researchers independently screened the literature, extracted the data and evaluated the risk of bias. Meta-analysis was performed by RevMan5.3 software.RESULTS Sixteen randomized controlled trials with 1 631 patients were included. The results of meta analysis showed that, compared with conventional western medicine, combined with Salvia Miltiorrhiza Ligustrazine Hydrochloride injection had better total efficacyOR=3.88, 95% CI(2.80, 5.37), P<0.000 01 in the treatment of angina. The levels of total cholesterolMD=-1.08, 95%CI(-1.36, -0.81), P<0.000 01, total triglycerideMD=-0.52, 95%CI(-0.66, -0.37), P<0.000 01 and low density lipoproteinMD=-0.74, 95%CI(-0.94, -0.55), P<0.000 1 in Salvia Miltiorrhiza Ligustrazine Hydrochloride injection group were lower than those in control group. The level of high density lipoprotein in Salvia Miltiorrhiza Ligustrazine Hydrochloride injection group was higher than that in control groupMD=0.28, 95%CI(0.20, 0.36), P<0.000 01. The incidence of adverse reactions of Salvia Miltiorrhiza Ligustrazine Hydrochloride injection group was lower than that of the control groupOR=0.57, 95%CI(0.30, 1.08), P=0.008.CONCLUSION Treatment combined with Salvia Miltiorrhiza Ligustrazine Hydrochloride injection has significant curative effect on angina pectoris and can effectively improve blood lipid level without increasing the incidence of adverse reactions.

       

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