Abstract: OBJECTIVE To introduce the research progress of linezolid plasma concentration monitoring. METHODS Relevant literature from February 2002 to April 2021 in PubMed, CNKI, WanFang Medical Network and FMJS were searched. The literatures related to efficacy and safety of linezolid under blood concentration monitoring were screened. The trough concentration range of efficacy and safety of linezolid under blood concentration monitoring was comprehensively analyzed. RESULTS A total of 156 literatures were retrieved, of which 30 were valid. The effective therapeutic valley concentration(C_min) of linezolid was different in patients with different infections, most studies thought it worked when C_min>2.0 mg·L^-1. That was, the low limit of the trough concentration range was usually 2 mg·L^-1. In terms of safety, at present, the determination of the high limit of the trough concentration range of linezolid in plasma was inconsistent, the lowest was 6.3 mg·L^-1, up to 22.1 mg·L^-1. CONCLUSION In clinical use of linezolid, blood concentration should be monitored in order to achieve the purpose of both ensuring the curative effect and reducing the occurrence of adverse events.