Abstract: OBJECTIVE To provide the selection basis for pharmaceutical management such as drug catalog adjustment and clinical application evaluation by multi-criteria quantitative evaluation of oral proton pump inhibitors in Hebei General Hospital. METHODS To establish a “Drug Quantitative Scoring Table” which based on 11 criterias: necessity, effectiveness, safety, economy, national medical insurance, national essential medicines, consistency evaluation, storage conditions, drug expiration dates, global usage, enterprise status. Ten oral proton pump inhibitors of 6 varieties were quantitatively evaluated by the information pharmacist. RESULTS Ten oral proton pump inhibitors scored between 52-78, omeprazole had the highest score and ilaprazole had the lowest score. The differences were mainly in the aspects of necessity and economy. CONCLUSION The multi-criteria quantitative evaluation of drugs provides comprehensive evidence for the drug and therapeutics committee. The management focus can be clarified by analyzing the score and dosage, which has the value of promotion and application.