Abstract: OBJECTIVE To evaluate the quality of Angelicae Dahuricae Radix(ADR) decoction pieces by the entropy weight method and grey relative analysis(GRA) method.METHODS The content of extracts, imperatorin, isoimperatorin, and the sum of the imperatorin and isoimperatorin in 49 batches of ADR decoction pieces from 36 pharmaceutical manufacturers were determined. GRA, the weight of the entropy weight method was used as the resolution coefficient to construct the quality research model of the decoction pieces.RESULTS The content of extracts in 49 batches of ADR decoction pieces were the largest, which suggested that the content might need to increase more indicative ingredients. The relative correlation degree of each evaluation unit sequence was 0.190 4-0.809 8, which indicated that the quality of ADR decoction pieces from different producing areas and manufacturers were different. Most of the manufacturers were in Hebei Province, the relative correlation degree measured was large, the quality ranking was in the front, the sulfur dioxide residue was more than 5 mg·kg^-1, the relative correlation degree measured was small, the quality ranking was in the back, indicating that the current standard needed to be improved, standardized processing management was conducive to the quality control of ADR decoction pieces. The top five samples were S46, S31, S39, S32, S36 based on these two methods.CONCLUSION The comprehensive quality evaluation of ADR decoction pieces can be effectively evaluated by GRA and entropy weight method. Entropy weight method improves the reliability of GRA method as well as the scientificity of quality evaluation of ADR decoction pieces.