Abstract: Glycyrrhiza polysaccharide is one of the main components of the leguminous plant Glycyrrhiza uralensis Fisch. Studies have shown that glycyrrhiza polysaccharide has a wide range of pharmacological effects, such as immune regulation, antioxidation, anti-tumor, bacteriostasis, anti-inflammatory, and regulation of intestinal flora. In this paper, the progress of pharmacological action and mechanism of glycyrrhiza polysaccharide was reviewed by searching the research reports of glycyrrhiza polysaccharide at home and abroad in recent years, so as to provide reference for the development and clinical application of glycyrrhiza polysaccharide in the future.