Abstract: OBJECTIVE To analyze the composition regularity of formulae containing Crataegi Fructus in Dictionary of Traditional Chinese Medicine Prescriptions, which provide reference for the guidance of clinical rational application and the further research and development of Crataegi Fructus. METHODS To collect the prescriptions containing Crataegi Fructus in Dictionary of Traditional Chinese Medicine Prescriptions, construct the database of clinical prescriptions, and use the software of IBM SPSS modeler 18.0 and SPSS statistics 22.0 to analyze the data of the frequency statistics, apriori algorithm and cluster analysis. RESULTS According to the inclusion and exclusion criteria, 1 088 prescriptions containing Crataegi Fructus were finally qualified, including mainly for 224 kinds of diseases. Among of them, the high frequency major syndrome and disease (frequency ≥ 16) were food stagnation, variola, dysentery and weakness of spleen and stomach. The data showed that there were 19 kinds of Chinese medicines frequency ≥ 200, and Citri Reticulatae Pericarpium, Glycyrrhizae Radix et Rhizoma and medicated leaven were used more frequently. The main types of medicines were qi-regulating medicine, food-digesting medicine and deficiency-tonifying medicine. In terms of properties, medicinals with warm nature were most frequently used. In terms of flavor, pungent, bitter and sweet medicinals were used often. According to meridian tropism, spleen, stomach, lung, liver meridian were used more frequently. The data of apriori algorithms and cluster analysis used for high-frequency disease showed Crataegi Fructus had apparently diverse effects in different diseases and compatibility. CONCLUSION Crataegi Fructus formula contained in the dictionary of Traditional Chinese Medicine has been widely used in clinic. They can be used not only for various diseases caused by stagnation of meat and blood stasis, but also for exogenous and skin diseases such as small pox, cold, sha tympany, and measles, breaking through the limitations of Crataegi Fructus in clinical and experimental research of modern traditional Chinese medicine. Using association rules and cluster analysis technology to mine the compatibility rules of high-frequency diseases and syndromes, it objectively, intuitively and scientifically reflects the unique efficacy and advantages of Crataegi Fructus in specific diseases and syndromes. It is of great significance to guide the rational clinical application of hawthorn Chinese medicine and develop health food and new Chinese medicine. What's more, it is helpful to promote the development of Chinese medicine great health industry in China.