基质补偿-电感耦合等离子体质谱法测定脂肪乳注射液中铝元素含量

Determination of Aluminum in Fat Emulsion Injection by ICP-MS with Matrix Compensation

摘要: 目的建立脂肪乳注射液中铝元素含量的电感耦合等离子体质谱法（ICP-MS）测定方法。方法采用基质饱和系统，直接稀释制样，在线内标引入方式，以电感耦合等离子体质谱法进行含量分析。结果铝离子浓度在1~30 ng·mL^-1线性关系良好，相关系数（r）为0.999 4，仪器精密度、重复性的RSD均<3%，方法检测限为1.04 μg·L^-1，加样回收率为102.0%~113.3%，RSD为3.6%（n=9）。结论本方法准确、灵敏高、简便可行，可为脂肪乳注射液铝元素含量测定提供有力技术保障。

Abstract: OBJECTIVE To establish an inductively coupled plasma mass spectrometry(ICP-MS) method for the determination of aluminum in Fat Emulsion injection. METHODS Using matrix saturation system, direct dilution preparation and online internal standard introduction, the content was analyzed by ICP-MS. RESULTS The linear range of aluminum was 1-30 ng·mL^-1, and the correlation coefficient(r) was 0.999 4, the RSDs of instrument precision and reproducibility were all <3%, the detection limit of the method was 1.04 μg·L^-1, and the recoveries were 102.0%-113.3% with RSD of 3.6%(n=9). CONCLUSION The method is accurate, sensitive, simple and feasible, and can provide strong technical support for the determination of aluminum in Fat Emulsion injection.