Abstract: OBJECTIVE To investigate the compatible stability of Xiangdan injection and Sodium Lactate Ringer's injection, and to provide reference for clinical safe medication. METHODS According to the amount of clinical application, Xiangdan injection was prepared with Sodium Lactate Ringer's injection. The appearance of the compatibility of solution, pH value, insoluble particles, ultraviolet spectrum and the contents of the salvianolic acid sodium, protocatechuic aldehyde, caffeic acid, lithospermic acid, salvianolic acid B, salvianolic acid A were determined. RESULTS The solution properties, pH value, UV spectrum had no change and particulate matter had decreased slightly within 6 h after the compatibility of Sodium Lactate Ringer's injection, and the content of lithospermic acid, salvianolic acid A had decreased by 17.41% and 78.64% respectively within 6 h after the compatibility of Sodium Lactate Ringer's injection, while the other contents had no change(<3%). CONCLUSION The content of effective components decreased within 6 h after Xiangdan injection and Sodium Lactate Ringer's injection compatibility. It is suggested not to infuse or infuse as soon as possible after compatibility to improve transfusion safety and effectiveness.