Abstract: OBJECTIVE To establish the fingerprint method of Shuangxiang antipyretic oral liquid and determine the contents of 4 index components simultaneously. METHODS The analysis was carried out on HP-5 capillary column(30 m×0.32 mm, 0.25 μm). The column temperature rose by program, the initial temperature was 110℃ and maintained for 10 min, then the temperature raised to 230℃ at a rate of 25℃·min^-1 and maintained for 9.2 min. Inlet temperature was 220℃, FID detector temperature was 220℃. High purity N₂(>99.99%) was used as the carrying gas, and the column flow was 1.0 mL·min^-1. The split ratio was 10:1, and the injection volume was 1 μL. RESULTS The preferable method for GC fingerprint of shuangxiang antifebrile oral liquid achieved, there were 13 common peaks in the GC fingerprints of 10 batches of samples, among which peaks 1, 2, 3 and 4 were from Moslae Herba, peaks 5, 6, 7 and 8 were from Magnoliae Officinalis Cortex, peaks 9-13 appeared in Moslae Herba and Magnoliae Officinalis Cortex and their negative control herbs, it was preliminarily presumed such components were the common components of them. According to the retention time, the no.1 peak was identified as thymol, no.2 peak as carvacrol, no.7 peak as magnolol, no.8 peak as honokiol. The linear ranges of the four index components were 0.226-2.260 mg·mL^-1, 0.105 5-1.055 0 mg·mL^-1, 0.082 8-0.828 0 mg·mL^-1, and 0.072 0-0.720 0 mg·mL^-1, respectively. The average recoveries were 100.1%-103.5%, 100.2%-104.4%, 99.4%-100.7% and 96.3%-99.27%; with the RSD was 2.8%, 2.1%, 2.4% and 2.1%, respectively. CONCLUSION The method is stable, reasonable and feasible, which provides scientific basis for the quality evaluation of the compound traditional Chinese medicine.