Abstract: OBJECTIVE To explore the research status, hotspots and frontier developments of individualized antitumor drugs at home and abroad, and provide ideas for related research in China. METHODS Searched related journals and review papers published in the Web of Science database from 2000 to 2020; used ISI Web of Knowledge's own analysis search results and create citation report functions, combined with CiteSpace5.0.R1SE software to draw a knowledge map. Summarized the number of articles published, the number of citations, the nationality of the researcher, the research institution, the research hotspot, and the research frontier in this field. RESULTS A total of 936 documents were included, and the number of documents in this field increased rapidly from 2000 to 2020. The United States and China took the lead due to a large number of publications. Research hotspots in this field included targeted therapy, pharmacogenomics, etc. Research frontiers in recent years included drug resistance research, molecular imaging, cancer systems biology models, etc. CONCLUSION The results of the analysis can provide valuable information for realizing the individualized medication of cancer patients, and alleviate the suffering of patients and reduce unnecessary expenditures.