Abstract: OBJECTIVE To establish a method for determination of multiple-indicator components of Qingfei oral-solution and to investigate its extraction process. METHODS The HPLC was performed to determine the content of chlorogenic acid, caffeic acid, p-coumaric acid, scutellarin, rosemary acid, and apigenin in Qingfei oral-solution. Chromatographic conditions:the mobile phase was 0.3% formic acid(A) and acetonitrile(B) with gradient elution at the flow rate of 1.0 mL·min^-1 and injection volume was 10 μL. The chromatographic column was Agilent Zorbax SB-C₁₈(4.6 mmx150 mm, 5 μm) and the column temperature was 35℃. The detection wavelength was 310 nm(0-25 min) and 330 nm(25-75 min). The effect of pure water amount, soaking time, number and time of reflux extraction on the extraction of multiple-indicator components from Qingfei oral-solution was studied via orthogonal design. RESULTS The calibration curve of chlorogenic acid, caffeic acid, p-coumaric acid, scutellarin, rosemary acid, and apigenin was linear over the range of 2.28-145.70 μg·mL^-1(r²=0.998 4), 3.07-196.70 μg·mL^-1(r²=0.998 9), 1.63-104.30 μg·mL^-1(r²=0.999 0), 1.49-95.20 μg·mL^-1(r²=0.998 8), 1.22-77.80 μg·mL^-1(r²=0.999 3) and 0.62-39.70 μg·mL^-1(r²=0.999 0). The average recoveries were 98.82%, 100.71%, 100.06%, 99.09%, 98.73%, 101.71% respectively. RSDs were 1.89%, 3.19%, 1.61%, 3.45%, 3.09%, 2.55% respectively. The optimum extraction process was as follows:8 times volumes of water was used as solvent to soak for 1 h and extract with reflux 2 times for 1.5 h per time. CONCLUSION The established method is simple, accurate and reproducible for determination of multiple-indicator components of Qingfei oral-solution. The optimal extraction process is stable and feasible.