Abstract: Microbial polysaccharides are high-molecular carbohydrates produced by microorganisms such as bacteria and fungi in the metabolic process. Microbial polysaccharides have diverse structures and functions, in addition, the production cycle of microorganisms is short, and the geographical environment will not affect the growth of microorganisms. What's more, the industrial production can be achieved through biological fermentation technology. Hence, it has a very broad application prospects in the fields of chemical industry, food, and medicine. This review summarizes the research progress of microbial polysaccharides such as xanthan gum, hyaluronic acid and bacterial cellulose in their physical and chemical properties, fermentation and wound application. Hoping to promote the in-depth study of microbial polysaccharides in wound and expand the market application of microbial polysaccharides.