Abstract: Age-related macular degeneration(AMD) is an ophthalmic disease that affects the function of the macular area of the retina and causes progressive damage to the central vision. It is a leading cause of visual impairment to elderly people aged over 60 years. With the deepening of Chinese society's aging process, the prevalence of AMD is gradually increasing. The molecular mechanisms underlying the specific pathogenesis of AMD is poorly understood. The construction of a suitable animal model is critical to clarifying the pathogenesis of AMD. Intricate risk factors have jointly promoted the occurrence and development of AMD. Therefore, analysis of AMD risk factors may showed some light on its animal construction.