Abstract: Disruption of the blood brain barrier(BBB) is one of the pathophysiological features of ischemic stroke, which will lead to neuroinflammation and hemorrhagic transformation. This paper summarize the research progress on the role of all kinds of histone deacetylase(HDAC) on BBB injury after ischemic stroke, and find that HDAC inhibitors that be used to target HDAC3, HDAC9 and Sirt5 or Sirt activators or be used to target Sirt3 and Sirt6, can reduce postoperative inflammation, reduce the risk of hemorrhagic transformation. Thus, it can save patients from BBB injury after ischemic stroke, extend the time window of r-tPA medication, and promote the recovery of patients' neurological function.