Abstract: OBJECTIVE To establish information management system for the special medical records of narcotic drugs provide, so as to provide reference for the information management of the special medical records of anesthetic drugs in hospitals. METHODS By reforming the hospital information system of Zhejiang Provincial People's Hospital, the special medical record management module of narcotic drugs was developed from three aspects:the office system of outpatient department, the doctor-side and the pharmacist-side. RESULTS After the information construction, the special medical records of narcotic drugs were managed intelligently, and the satisfaction of doctors and patients was greatly improved. CONCLUSION The informatization construction of special medical records of narcotic drugs can greatly improve work efficiency, ensure the safe and rational use of narcotic drugs in clinical practice, and make the management of narcotic drugs more scientific and operable, which is worth promoting.