Abstract: OBJECTIVE To report a case of antibiotic therapy in a patient with premature rupture of membranes(PROM) and intra-amniotic infection(IAI) with Pseudomonas aeruginosa(PA), discussed the reason of the poor initial effect of the local cervical treatment and the strategy of treatment in PA antibiotic therapy. METHODS Clinical pharmacists participated in the adjustment of patients' drug treatment plan, considering the current resistance of PA and the patient's own situation, clinical pharmacists suggested physicians to adjust the strategy of drug treatment. RESULTS After piperacillin sodium/tazobactam was applied for a week, the symptoms of the patient were obviously improved. CONCLUSION Clinical pharmacists participate in the clinical treatment, provide a reasonable clinical treatment program with physicians, can make the medication more safe, effective and reasonable for patients.