Abstract: OBJECTIVE To establish the pharmacist's management system of chronic heart failure patient in outpatient and emergency room, and to explore the effect of pharmacist's instruction of standardized medication therapies for patients. METHODS To establish the pharmacist's management system of chronic heart failure patient in Beijing Shijitan Hospital Affiliated to Capital Medical University and Tongliao Second People's Hospital of Inner Mongolia. Physicians and pharmacists cooperated in making individualized medication treatment plans for patients with chronic heart failure, to evaluate the renin angiotensin aldosterone system(RAAS) inhibitors and β receptor blockers usage and ratio of treatment dose reached target dose, the changes of cardiac function and cardiac structure, biochemical indexes and drug safety before and after treatment. RESULTS The ratio of RAAS inhibitor treatment dose and the β receptor blockers treatment dose reached target dose in follow up patients were all 80.0%. After standardized drug treatment, the patients' cardiac function was significantly improved compared with before treatment, and the left ventricular ejection fractions(LVEF) of the patients with increased left ventricular end diastolic diameter(LVEDD) increased significantly and LVEDD decreased significantly. After the pharmacists' follow-up intervention, the parameter of heart rate, blood pressure, NT-proBNP, albumin and blood potassium were significantly improved compared with before intervention. During the follow-up period, 3 patients died of malignant heart failure; other patients had no symptomatic hypotension and were well tolerated. CONCLUSION With the establishment of the pharmacists' follow-up to instruct the standardized medication therapy of chronic heart failure patients in outpatient and emergency room, most patients' RAAS inhibitors and β receptor blockers and other medications' usage can reach the target dose recommended by the guidelines, and obtain satisfactory clinical efficacy and safety.